Services - Biologics - Coagulation
ACT (Activated Clotting Time): The ACT test uses kaolin/celite as the initiator of coagulation. The test is used to assess the degree of inhibition of the intrinsic pathway of blood coagulation that is initiated by contact activation such as foreign surfaces or oxygen. For this reason, the ACT test is used frequently during CABG surgery to monitor heparin anticoagulation.
Heparin Dose Response (HDR): The anticoagulant heparin is used during CABG surgery, kidney dialysis and in the cath lab (during angioplasty and stent placements). The response to heparin is affected by individual variations and hence the HDR is a critical measure to ensure effective heparin anticoagulation in each patient.
Heparin Protamine Titration (HPT): The most effective way to monitor anticoagulation during CABG surgery is to measure heparin directly in a point-of-care IVD test. One technical approach is to use a HPT to measure blood heparin levels.
PT (Prothrombin Time): The PT test uses thromboplastin as the initiator of coagulation. The PT test is used to assess the degree of inhibition of the extrinsic pathway of blood coagulation (that is initiated by tissue factor and is sensitive to the plasma levels of blood clotting factors). For this reason the PT test is used clinically to monitor coumadin therapy.
Platelet Function: Platelets are an essential component of effective hemostasis and measuring their function during critical surgical procedures, such as CABG surgery, can lead to more effective clinical intervention to control post operative bleeding.
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